Endometrial Cancer & Nutrition: What You Need to Know

January is cervical cancer awareness month, and this is especially poignant for me.  Cervical cancer is one type of estrogen-linked cancer.  Last January, my Mom passed away from another type of estrogenic cancer – endometrial cancer (also called uterine cancer).  Losing my Mom and knowing what I now know about nutrition and lifestyle and cancer, I wish we had had that information sooner.  

As I reflect on that time in my life, I turn to one of my favorite mantras: “Turn pain into purpose.”  The pain of her death is jet fuel to my mission of helping people regain their quality of life so they can live their lives with confidence, radiance, and vitality.  

Estrogenic cancers, such as breast and endometrial (uterine) cancer, are influenced by the hormone estrogen and have been linked to various risk factors – several of which are WITHIN your power to change.

Your diet has a pivotal role in contributing to or mitigating these risks, making functional nutrition a significant area of interest for those concerned about estrogen-related cancers. Functional nutrition confirms the foods you should be eating based off of cutting-edge testing. In the mainstream media, there are several foods that are touted as healthy, but what may be healthy for some, may not be healthy for you! 

You may have heard you need to eat plant-based, but in the case of one of my clients, when she began eating that way, she experienced more bloating, pain and discomfort. 

Why? Because when we tested, she had quite a few opportunistic (unfriendly) gut pathogens which were impacting his ability to break down plant foods and legumes. So the first step is really dialing in your nutrition so that it is working for you – not against you, regardless of what the mainstream or influencers say! 

Personalized nutrition can be life changing in the prevention of estrogenic cancers. 

Then there are minerals! By understanding how certain minerals interact with your body’s hormonal balance and metabolic processes, you can make informed decisions that support creating health in your body. Replacing processed foods with whole, nutrient-rich options, while improving nutrient absorption, and reducing toxin exposure, for example, could potentially modify estrogen levels and metabolism, providing a protective impact against female cancer incidence.

Key Takeaways

• Your diet plays a crucial role in the risk and management of estrogenic cancers.
• Functional nutrition focuses on the preventive and therapeutic potential of diet.
• Lifestyle modifications can enhance quality of life and complement traditional cancer treatments.

Understanding Estrogenic Cancers

Estrogenic cancers are a group of malignancies fueled by the hormone estrogen. These cancers have specific types, risk factors, biological mechanisms, and standard treatments that are critical to the understanding of their development and management.

Types and Risk Factors

Estrogenic cancers primarily include breast cancer, ovarian cancer, prostate cancer, cervical cancer, and endometrial cancer. Your cancer risk is influenced by both genetic factors, environmental toxins like heavy metals and mold, as well as lifestyle practices like sleep, exercise, nutrition and even your close interpersonal relationships.

Genetic mutations, such as those in the BRCA1 and BRCA2 genes, significantly increase the risk, particularly for breast and ovarian cancers. But these are NOT the only genes to be mindful of.  Looking for genetic variations or SNPs (single nucelotide polymorphisms) on the COMT, MTHFR, MTRR will give insight into estrogen metabolism and methylation – 2 processes that are crucial for understanding the way the body handles breaking down estrogen! 

Additional risk factors include aging, waist-to-hip ratio, smoking, vitamin levels, Hormone Replacement Therapy (HRT), and obesity.

• Breast Cancer: Most common type of cancer in women, often estrogen receptor-positive.
• Ovarian Cancer: Less common but has a higher mortality rate due to late-stage discovery.
• Prostate Cancer: Can be driven by estrogen in addition to androgens.
• Cervical Cancer: Has been associated with hormonal factors among other causes.
• Endometrial / Uterine Cancer: Strongly linked to estrogen levels; most common gynecologic cancer in developed countries.

A little more about endometrial cancer, since it’s the type my Mom had…

Endometrial cancer is classified as a cancer of the uterus.  Technically, it’s a cancer of the endometrial lining (aka uterine lining).
 Endometrial cancers are adenocarcinomas, which means they’re a cancer of the glands that line the uterus. It is the most common cancer of the female reproductive system.  

Diagnosis can be a little tricky, because there are only a few signs and symptoms of endometrial and uterine cancer.  (So, knowing your risk of endometrial cancer is important.)  Unusual discharge, spotting, or bleeding, especially after menopause, is the most common warning sign.  

In later stages, there may be a mass, weight loss, and/or pelvic pain.  Although many women may not want to discuss these personal symptoms with a doctor, it’s vital to do so to avoid spread to other parts of the body (called metastasis).  

Endometrial cancer is usually found in post-menopausal women aver the age of 60. It’s more common in African American women.  A family history of endometrial cancer increases your risk for endometrial cancer, but a healthy lifestyle can greatly mitigate that risk.  To learn more about endometrial cancer – including information on the risk, diagnosis, and conventional ttreatment of endometrial cancer – visit the American Cancer Society website.

Biology and Mechanisms

Estrogens contribute to cancer development by promoting cell proliferation, leading to DNA damage and oxidative stress. They also influence inflammation in the cellular environment, which can contribute to cancer progression. The hormone plays a dual role in apoptosis, or programmed cell death; it can both induce and inhibit the process depending on the context within specific cancer cells.

• Cell Proliferation: Cancer starts when estrogen binds to receptors on cells, signaling them to divide.
• DNA Damage: Over-proliferation can lead to errors in DNA replication.
• Oxidative Stress: Can result from estrogen metabolism and contribute to cancer development.
• Apoptosis: Compromised in cancer cells, sometimes due to estrogen signaling.

Diagnosis and Standard Cancer Treatments

The diagnosis of an estrogenic cancer typically involves imaging tests like mammograms, ultrasounds, or transvaginal ultrasounds, followed by an endometrial biopsy from the lining of the uterus to confirm the presence of cancer cells. Once diagnosed, clinical outcomes depend on the stage of cancer and type of cancer.

Standard treatments for estrogenic cancers may include:

• Surgery: To remove tumors or affected organs.
• Chemotherapy: Systemic treatment to kill or slow the growth of cancer cells. (Most common type of breast cancer treatment)
• Radiation Therapy: Using high-energy radiation to destroy cancer cells.
• Hormonal Therapy: Blocks cancer’s estrogen fuel, used in breast and prostate cancers.

These treatments – often referred to as “slash and burn” – are, in my opinion, erroneously disease-focused. And as such, they not only kill the cancer, but often kill the person who has the disease, because they’re not focused on WHY the cancer has originated in the first place. 

My own mother was convinced because she had a hysterectomy, chemo and radiation, that she was done with cancer and she could revert to eating foods that were unhealthy (cakes, donuts, etc..) However, despite getting an all clear in the summer of 2018, but by the end of 2020, her cancer had returned, stronger than ever and chemo in this instance is what actually killed her. Her doctors did not understand that even if they remove a cancerous cell surgically, the processes that caused that cell to become cancerous, were still at play… and they failed to educate her on that, and by the time she caught on to the fact that her diet and lifestyle – she hated drinking water – were actually harming her, it was very late in the day. 

Functional Nutrition in Cancer Management

In managing estrogenic cancers, functional nutrition can be life-changing. 

Dietary Components and Cancer Dynamics

Your diet is a pivotal factor in cancer development and progression. Foods rich in antioxidants, fiber, and certain vitamins like vitamin C and carotenoids are shown to positively influence the body’s defense against cancer. For instance, the phytonutrients found in vegetables and fruits reduce  cancer risk. On the contrary, diets high in sugar may contribute to an unfavorable environment for cancer progression.  One of my personal bug bears with the plant-based world is the lack of understanding of the need for macro-nutrient balance.

Research, including systematic reviews and meta-analyses, consistently supports the correlation between specific dietary patterns, like the Mediterranean diet, and lower incidences of estrogenic cancers. A diet rich in healthy fats, lean proteins, and a variety of vegetables not just supports overall health but specifically targets cancer pathways.

Nutritional Strategies During Treatment

If you have reached a place where you’re going through chemo, you have to remember to support your body’s unique nutritional needs. Functional foods, those that offer more than basic nutrition, can play a critical role here. For example, ginger and peppermint may help alleviate nausea, while protein-rich foods can aid in preventing sarcopenia and cachexia, the muscle-wasting often associated with cancer treatments.

It is well-documented that malnutrition can be a side effect of cancer or its treatment, potentially impacting the outcome negatively. Ensuring adequate intake of calcium and vitamin D supplements, when necessary, alongside a diet tailored to support clinical nutrition needs is essential.

Prevention and Post-Treatment Nutrition

Aiming for cancer prevention and recovery, a personalized diet tailored to your Metabolic Type, while eliminating your Food Sensitivities and Toxins like plastic, Petrochemicals and Metals, along with regular movement, is your best strategy.

Post-treatment, your focus should be on maintaining a diet that continues to support the body’s recuperative processes and reduces the risk of recurrence. Increased vegetable consumption and adherence to diets like the Mediterranean diet, which are dense in nutrients and low in processed foods, are recommended.

Observational studies suggest that lifestyle changes including exercise and a diet that emphasizes functional foods—those with potentially beneficial effects on health beyond basic nutrition—such as vegetables, fruits, and a controlled intake of red meats can be successful strategies for sustaining health post-cancer treatment. Traditional dietary approaches also include whole grains, however I hesitate to support this recommendation due to the level of pesticides like Glyphosate that are sprayed on grains. Glyphosate itself is carcinogenic, and eating grains can be very high in carbohydrates which turn into sugar, which feeds cancer…  

Lifestyle Modifications and Complementary Approaches

Understanding how daily habits and dietary choices can impact estrogenic cancers is crucial. You can take active steps towards reducing your cancer risk through specific lifestyle modifications and implementing complementary approaches.

Importance of Detoxification

Detoxification processes in your body are critical for metabolizing estrogens and reducing cancer risk. Regular sweating through infrared sauna and supporting the liver is a key component to reducing risk.

If you want to also support the liver through nutrition, consuming cruciferous vegetables like broccoli and cauliflower can help the detoxification process. Additionally, reducing alcohol consumption and avoiding smoking are significant, as these habits can burden your liver, hindering its ability to detoxify properly.

I want to take a moment to underscore the fact that we live in a highly toxic world.  

For an interesting (and scary!) read, you can receive a free copy of the report “Body of Evidence” from the Natural Resource Council of Maine.   This study looked at a small sample of people in Maine (considered a “green” state by most!) and found a total of 46 different chemicals (of 71 tested) in samples of blood, urine, and hair. On average, each participant had measurable levels of 36 toxic chemicals in their bodies!!

You can also check out a more recent article on the pollution of people by the Environmental Working Group, a non-profit organization dedicated to the health of our planet and its inhabitants.

The human body was not meant to handle the number and quantity of toxins we’re now exposed to on a daily basis.  Therefore, it’s imperative that we help our bodies reduce the toxic burden by actively taking steps to reduce our exposure to chemicals and toxins.  Some of the easiest steps to take are:

1. Choose local and organic foods free of herbicides and insecticides when possible as these reduce the toxic burden on the liver.  There are several free apps you can download to help you find Farmers Markets near you.  The “Dirty Dozen” list of produce that should always be purchased organic and the “Clean Fifteen” list of produce that can be purchased conventionally are updated annually.
2. Use organic castor oil packs to help your body detox in a variety of ways.  I love Queen of Thrones products!  (Full disclosure: If you click and purchase, I may receive a small commission at no extra cost to you.  I only recommend products I personally use that have helped me and my clients!)
3. Invest in a high-quality water filter that is appropriate for your space and environment.  My favorite one is the MegaHome Distiller.  Distilled water is one of my favorite tools in the fight against environmental toxins like heavy metals and mold – which can be major contributors to development of cancer. Drinking an abundance of clean water that is pesticide, fluoride and pathogen free is a great tool in prevention! 
   For additional information on the tap water in YOUR area, check out the Tap Water Database hosted by the Environmental Working Group. I’ve also learned that even well water has its risks. I live on a well and it’s high in uranium, and manganese (luckily no pathogens or parasites!).
4. Invest in a high-quality air purifier that is appropriate for your space and environment.  My favorite is the Austin Air.
5. Change to non-toxic cleaning and personal care products.  The Environmental Working Group maintains a database of cleaning and personal care products called EWG Verified.
6. Switch to non-toxic beauty products.  Once again, the Environmental Working Group has a database for that!  You can access the Skin Deep database, enter in your favorite products, and see how they rate.  Their easy ranking system will also help you select less toxic products!

Impact of Alternative Diets and Supplements on Cancer Risk

Choosing an alternative diet like the Mediterranean diet, rich in omega-3 fatty acids, can contribute to lower inflammation and possibly reduce cancer risk. High quality supplements containing antioxidants such as vitamin A, vitamin D, vitamin E, and compounds like lycopene, β-carotene, α-carotene, and β-cryptoxanthin may also be beneficial. However, it’s essential to consult with a healthcare provider before starting any new supplements.

• Omega-3s: Found in fish, flax seeds, and walnuts.
• Vitamins A and D: Found in liver, dairy products, and fish oils.
• Vitamins E: Found in nuts, seeds, and green leafy vegetables.
• Carotenoids: Found in colorful fruits and vegetables.

Behavioral Factors and Cancer Prognosis

Your lifestyle behaviors significantly impact your cancer prognosis and overall quality of life. Regular exercise can lower your risk of developing estrogenic cancers, improve your cardiovascular health, and boost your quality of life. Limiting sugar-sweetened beverages and decreasing sugar intake are also important dietary considerations. Instead of sugary drinks, opt for water or unsweetened coffee and tea, which provide hydration without the negative impacts of sugar. Reducing alcohol intake and quitting smoking are key behavioral changes that can positively influence your prognosis.  Stress management and a focus on the spiritual side of life are also key.  This can include prayer, meditation, a daily gratitude practice, and more.

Conclusion

For more detailed information on how certain foods and dietary patterns can affect estrogen metabolism and its association with breast cancer risk, explore further through research articles and systematic reviews. Additionally, consider examining the specific dietary patterns that have been associated with estrogen metabolism.

Key Dietary Considerations:

• Drink distilled water all day  
• Test your Metabolic Type and Food Sensitivities and then incorporate foods with the potential to modulate estrogen metabolism, sulfurophane and fish high in ω-3 fatty acids.
• Limit intake of sugars, processed meats, and refined grains, which might negatively affect estrogen-related pathways.
• Remember, individual responses to dietary patterns can vary; consult with a Functional Nutrition Practitioner to tailor a plan that suits your unique needs. 

Nutrition plays a crucial role in managing and potentially reducing the risk of estrogenic cancers. By understanding the impact of nutrition, the environment and your levels of activity on hormonal balance, you can make informed choices that may benefit your long-term health.  If you’re ready to start 2024 off right, join the Master the Basics Health Foundation Online Program!  It includes functional labs, personalized recommendations, and is supported by an online community. Make the decision that could change your life — I hope to see you on the inside!

Frequently Asked Questions

In this section, you’ll find direct answers to common inquiries regarding dietary impact on estrogen-related cancers and the role of functional nutrition in cancer prevention and management.

What specific dietary changes can reduce the risk of estrogen-related cancers?

Incorporating phytoestrogen-rich foods like flaxseeds may help regulate estrogen levels. Reducing consumption of high-fat animal products can also be beneficial for lowering your risk of hormone-related cancers.

Which foods have been scientifically proven to combat cancer cells naturally?

Foods like cruciferous vegetables, specifically broccoli and kale, contain compounds such as sulforaphane and indole-3-carbinol, which have been shown to inhibit cancer cell growth.  Garlic and certain mushrooms have been shown in some studies to stop cancer cells from growing.

What are some cancer-fighting functional foods recommended for breast cancer patients?

Breast cancer patients are often advised to eat foods rich in antioxidants, like berries, and omega-3 fatty acids, found in fatty fish such as salmon, to help reduce inflammation and potentially slow the progression of cancer cells.

Which foods should individuals with estrogen-positive breast cancer avoid?

Individuals with estrogen-positive breast cancer may benefit from avoiding alcohol and limiting refined sugars and processed meats, which are linked to increased cancer risk.

What are effective dietary strategies for cancer prevention that have been supported by research?

Knowing Your Metabolic Type minus your Food Sensitivities while including a variety of fruits, vegetables, and limit processed and red meats are dietary strategies supported by research for reducing cancer risk.

Where can I obtain more information about female hormone cancers?

To learn more about endometrial cancer (a type of uterine cancer) – I recommend reading Dr Nasha Winters’ book, The Metabolic Approach to Cancer. She’s a Naturopathic Doctor who reversed her own breast cancer and has helped thousands of women do the same with their female hormones cancers. 

How do I know if I’m at increased risk for a female hormone cancer and how is endometrial cancer detected?

Non-modifiable risk factors for cancer of the endometrium include: Age (over 60), sex (female), race (African American), and a family member diagnosed with endometrial cancer.  Modifiable risk factors (those you can change) include: Smoking, drinking, liver function, sedentary lifestyle, poor nutrition / lack of key nutrients, exposure to toxins,  and more.  As you can see, you have a lot of control over your risk of developing endometrial cancer!

What is the best treatment for endometrial cancer?

Standard treatment options are disease-focused (radiation, chemotherapy, etc.).  However, the Functional and Natural Health world offers respite from focusing on killing, with a focus on creating life. When you really look at a person from the inside out – your genes, your food, the home or office you’re in, as well as the relationships you’re in, you actually understand how to get your body to work well, decrease your risk factors, support your immune system, and live as God intended you to live – abundantly.  

References:

Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M. Risk factors for endometrial cancer: An umbrella review of the literature. Int J Cancer. 2019 Oct 1;145(7):1719-1730. doi: 10.1002/ijc.31961. Epub 2019 Feb 20. PMID: 30387875.

Wang X, Glubb DM, O’Mara TA. Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study. Nutrients. 2023 Jan 24;15(3):603. doi: 10.3390/nu15030603. PMID: 36771310; PMCID: PMC9920466.

Parida S, Sharma D. The Microbiome-Estrogen Connection and Breast Cancer Risk. Cells. 2019 Dec 15;8(12):1642. doi: 10.3390/cells8121642. PMID: 31847455; PMCID: PMC6952974.

Zhao H, Zhou L, Shangguan AJ, Bulun SE. Aromatase expression and regulation in breast and endometrial cancer. J Mol Endocrinol. 2016 Jul;57(1):R19-33. doi: 10.1530/JME-15-0310. Epub 2016 Apr 11. PMID: 27067638; PMCID: PMC5519084.

Steck SE, Murphy EA. Dietary patterns and cancer risk. Nat Rev Cancer. 2020 Feb;20(2):125-138. doi: 10.1038/s41568-019-0227-4. Epub 2019 Dec 17. PMID: 31848467.

Greathouse KL, Wyatt M, Johnson AJ, Toy EP, Khan JM, Dunn K, Clegg DJ, Reddy S. Diet-microbiome interactions in cancer treatment: Opportunities and challenges for precision nutrition in cancer. Neoplasia. 2022 Jul;29:100800. doi: 10.1016/j.neo.2022.100800. Epub 2022 Apr 29. PMID: 35500546; PMCID: PMC9065883.

Lane J, Brown NI, Williams S, Plaisance EP, Fontaine KR. Ketogenic Diet for Cancer: Critical Assessment and Research Recommendations. Nutrients. 2021 Oct 12;13(10):3562. doi: 10.3390/nu13103562. PMID: 34684564; PMCID: PMC8539953.

Dayi T, Oniz A. Effects of the Mediterranean diet polyphenols on cancer development. J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E74-E80. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2749. PMID: 36479482; PMCID: PMC9710397.

Carlberg C, Velleuer E. Vitamin D and the risk for cancer: A molecular analysis. Biochem Pharmacol. 2022 Feb;196:114735. doi: 10.1016/j.bcp.2021.114735. Epub 2021 Aug 16. PMID: 34411566.

Muñoz A, Grant WB. Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. Nutrients. 2022 Mar 30;14(7):1448. doi: 10.3390/nu14071448. PMID: 35406059; PMCID: PMC9003337.

Darbre PD. Endocrine disrupting chemicals and breast cancer cells. Adv Pharmacol. 2021;92:485-520. doi: 10.1016/bs.apha.2021.04.006. Epub 2021 Jul 28. PMID: 34452695.

Murillo G, Mehta RG. Cruciferous vegetables and cancer prevention. Nutr Cancer. 2001;41(1-2):17-28. doi: 10.1080/01635581.2001.9680607. PMID: 12094621.

Mokbel K, Mokbel K. Chemoprevention of Breast Cancer With Vitamins and Micronutrients: A Concise Review. In Vivo. 2019 Jul-Aug;33(4):983-997. doi: 10.21873/invivo.11568. PMID: 31280187; PMCID: PMC6689356.

Kerr J, Anderson C, Lippman SM. Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. Lancet Oncol. 2017 Aug;18(8):e457-e471. doi: 10.1016/S1470-2045(17)30411-4. Epub 2017 Jul 26. PMID: 28759385; PMCID: PMC10441558.

Klein WMP, O’Connell ME, Bloch MH, Czajkowski SM, Green PA, Han PKJ, Moser RP, Nebeling LC, Vanderpool RC. Behavioral Research in Cancer Prevention and Control: Emerging Challenges and Opportunities. J Natl Cancer Inst. 2022 Feb 7;114(2):179-186. doi: 10.1093/jnci/djab139. PMID: 34240206; PMCID: PMC8344826.

Kripke M, Brody JG, Hawk E, Hernandez AB, Hoppin PJ, Jacobs MM, Rudel RA, Rebbeck TR. Rethinking Environmental Carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):1870-1875. doi: 10.1158/1055-9965.EPI-20-0541. PMID: 33004408.

Encarnação T, Pais AA, Campos MG, Burrows HD. Endocrine disrupting chemicals: Impact on human health, wildlife and the environment. Sci Prog. 2019 Mar;102(1):3-42. doi: 10.1177/0036850419826802. Epub 2019 Jan 1. PMID: 31829784; PMCID: PMC10424550.

Wiggs AG, Chandler JK, Aktas A, Sumner SJ, Stewart DA. The Effects of Diet and Exercise on Endogenous Estrogens and Subsequent Breast Cancer Risk in Postmenopausal Women. Front Endocrinol (Lausanne). 2021 Sep 20;12:732255. doi: 10.3389/fendo.2021.732255. PMID: 34616366; PMCID: PMC8489575.

Bak MJ, Das Gupta S, Wahler J, Suh N. Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. Semin Cancer Biol. 2016 Oct;40-41:170-191. doi: 10.1016/j.semcancer.2016.03.001. Epub 2016 Mar 22. PMID: 27016037; PMCID: PMC5033666.

Guinter MA, McLain AC, Merchant AT, Sandler DP, Steck SE. A dietary pattern based on estrogen metabolism is associated with breast cancer risk in a prospective cohort of postmenopausal women. Int J Cancer. 2018 Aug 1;143(3):580-590. doi: 10.1002/ijc.31387. Epub 2018 Apr 6. PMID: 29574860; PMCID: PMC6019153Then.